|
Myeloid Leukemia, Chronic
|
|
0.800 |
GeneticVariation
|
CLINVAR |
BCR-ABL tyrosine kinase inhibitors in the treatment of Philadelphia chromosome positive chronic myeloid leukemia: a review.
|
20537386 |
2010 |
|
Myeloid Leukemia, Chronic
|
|
0.800 |
GeneticVariation
|
CLINVAR |
BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet.
|
21562040 |
2011 |
|
Myeloid Leukemia, Chronic
|
|
0.800 |
GeneticVariation
|
CLINVAR |
Use of direct sequencing for detection of mutations in the BCR-ABL kinase domain in Slovak patients with chronic myeloid leukemia.
|
21895409 |
2011 |
|
Myeloid Leukemia, Chronic
|
|
0.800 |
GeneticVariation
|
CLINVAR |
Mutations in ABL kinase domain are associated with inferior progression-free survival.
|
20367437 |
2010 |
|
Myeloid Leukemia, Chronic
|
|
0.800 |
GeneticVariation
|
CLINVAR |
The mutation status of 65 patients with resistant CML was evaluated, and the T315I was detected in 3/65 (4.6%).
|
20512393 |
2011 |
|
Myeloid Leukemia, Chronic
|
|
0.800 |
GeneticVariation
|
CLINVAR |
BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: a prospective study.
|
11853795 |
2002 |
|
Myeloid Leukemia, Chronic
|
|
0.800 |
GeneticVariation
|
CLINVAR |
Frequent EVI1 translocations in myeloid blast crisis CML that evolves through tyrosine kinase inhibitors.
|
21872826 |
2011 |
|
Myeloid Leukemia, Chronic
|
|
0.800 |
GeneticVariation
|
CLINVAR |
Early detection and quantification of mutations in the tyrosine kinase domain of chimerical BCR-ABL1 gene combining high-resolution melting analysis and mutant-allele specific quantitative polymerase chain reaction.
|
22870928 |
2013 |
|
Myeloid Leukemia, Chronic
|
|
0.800 |
GeneticVariation
|
CLINVAR |
The two major imatinib resistance mutations E255K and T315I enhance the activity of BCR/ABL fusion kinase.
|
15194504 |
2004 |
|
Myeloid Leukemia, Chronic
|
|
0.800 |
GeneticVariation
|
CLINVAR |
Rapid quantitative detection of the T315I mutation in patients with chronic myelogenous leukemia.
|
22306673 |
2012 |
|
Myeloid Leukemia, Chronic
|
|
0.800 |
GeneticVariation
|
CLINVAR |
High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance.
|
11964322 |
2002 |
|
Myeloid Leukemia, Chronic
|
|
0.800 |
GeneticVariation
|
CLINVAR |
High incidence of BCR-ABL kinase domain mutations and absence of mutations of the PDGFR and KIT activation loops in CML patients with secondary resistance to imatinib.
|
14745431 |
2004 |
|
Myeloid Leukemia, Chronic
|
|
0.800 |
GeneticVariation
|
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
|
Myeloid Leukemia, Chronic
|
|
0.800 |
GeneticVariation
|
CLINVAR |
Ponatinib is a pan-BCR-ABL kinase inhibitor: MD simulations and SIE study.
|
24236021 |
2013 |
|
Myeloid Leukemia, Chronic
|
|
0.800 |
GeneticVariation
|
CLINVAR |
Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment.
|
12130516 |
2002 |
|
Myeloid Leukemia, Chronic
|
|
0.800 |
GeneticVariation
|
CLINVAR |
Detection of BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia on imatinib.
|
23676790 |
2013 |
|
Myeloid Leukemia, Chronic
|
|
0.800 |
GeneticVariation
|
CLINVAR |
In the present study, an allele-specific oligonucleotide reverse transcriptase polymerase chain reaction assay was used to detect T315I mutation in a cohort of 60 imatinib-resistant CML patients.
|
23540562 |
2013 |
|
Myeloid Leukemia, Chronic
|
|
0.800 |
GeneticVariation
|
CLINVAR |
Contribution of BCR-ABL kinase domain mutations to imatinib mesylate resistance in Philadelphia chromosome positive Malaysian chronic myeloid leukemia patients.
|
23355941 |
2012 |
|
Myeloid Leukemia, Chronic
|
|
0.800 |
GeneticVariation
|
CLINVAR |
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification.
|
11423618 |
2001 |
|
Myeloid Leukemia, Chronic
|
|
0.800 |
GeneticVariation
|
CLINVAR |
Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy.
|
12399961 |
2002 |
|
Myeloid Leukemia, Chronic
|
|
0.800 |
GeneticVariation
|
CLINVAR |
We report a chronic-phase CML patient undergoing IM treatment, who showed the overt existence of the T315I mutation after 15 months.
|
20963643 |
2010 |
|
Myeloid Leukemia, Chronic
|
|
0.800 |
GeneticVariation
|
CLINVAR |
Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis.
|
12623848 |
2003 |
|
Myeloid Leukemia, Chronic
|
|
0.800 |
GeneticVariation
|
CLINVAR |
Low-level Bcr-Abl mutations are very rare in chronic myeloid leukemia patients who are in major molecular response on first-line nilotinib.
|
21762985 |
2011 |
|
LEUKEMIA, PHILADELPHIA CHROMOSOME-POSITIVE, RESISTANT TO IMATINIB
|
|
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
Acute lymphoblastic leukemia with lymphomatous features
|
|
0.700 |
GeneticVariation
|
CLINVAR |
MK-0457, an Aurora kinase and BCR-ABL inhibitor, is active in patients with BCR-ABL T315I leukemia.
|
22772060 |
2013 |